Regulation of presynapse organization

Across TCGA patient cohorts, RNA activity of the Regulation of presynapse organization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP3K13, C1QTNF3, and CD79A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of presynapse organization activity versus MAP3K13 in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP3K13 →	+0.707	+0.277	<.001	.009	3	5
BRCA	C1QTNF3 →	+0.841	+0.256	.002	.005	3	5
HNSC	CD79A →	-1.358	-0.137	<.001	.008	3	5
PDAC	NUGGC →	-0.479	-0.189	<.001	<.001	3	5
GBM	SLAMF1 →	-0.429	-0.224	.001	.006	3	5
HNSC	VILL →	-0.627	-0.161	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099174 vs MAP3K13 — LSCC

Explore this scatter interactively →