Postsynapse organization

Across TCGA patient cohorts, RNA activity of the Postsynapse organization pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GRAP2, TMF1, and CD48, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse organization activity versus GRAP2 in GBM (Pearson r = -0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRAP2 →	-0.739	-0.064	<.001	<.001	3	6
LSCC	TMF1 →	-0.284	-0.030	<.001	<.001	3	6
LSCC	CD48 →	-0.530	-0.022	<.001	.008	3	6
LSCC	GMPPB →	-0.389	-0.031	<.001	<.001	3	6
HNSC	RFTN1 →	-0.269	-0.032	.004	.001	3	5
BRCA	METTL7A →	-0.525	-0.018	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099173 vs GRAP2 — GBM

Explore this scatter interactively →