Postsynapse organization

Across TCGA patient cohorts, RNA activity of the Postsynapse organization pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAPLN, PDYN, and RASL12, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse organization activity versus PAPLN in COAD (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PAPLN →	+0.633	+0.910	.001	.006	3	1
COAD	PDYN →	+0.018	+1.032	.004	.002	3	1
COAD	RASL12 →	+0.731	+1.177	<.001	<.001	3	1
COAD	SLC6A13 →	+0.045	+0.939	.001	.001	3	1
COAD	FCGRT →	+0.781	+1.003	<.001	.001	3	1
COAD	TFPT →	+0.279	+0.809	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099173 vs PAPLN — COAD

Explore this scatter interactively →