Postsynapse organization

Across TCGA patient cohorts, RNA activity of the Postsynapse organization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCOR1_S260, REPS1_S170, and RNF20, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse organization activity versus RCOR1_S260 in COAD (Pearson r = -0.15).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RCOR1_S260 →	-0.336	-0.910	<.001	<.001	3	1
COAD	REPS1_S170 →	-0.503	-1.162	<.001	<.001	3	1
COAD	RNF20 →	-0.215	-0.976	<.001	<.001	3	1
COAD	RPL4_S295 →	-0.690	-1.101	<.001	<.001	3	1
COAD	RPRD2_S665 →	-0.317	-1.239	<.001	<.001	3	1
COAD	RPRD2_S909 →	+1.086	+1.601	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099173 vs RCOR1_S260 — COAD

Explore this scatter interactively →