Postsynapse organization

Across TCGA cell cohorts, RNA activity of the Postsynapse organization pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAPN2, TP53I13, and CABYR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynapse organization activity versus CAPN2 in BREAST (Pearson r = 0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CAPN2 →	+1.404	+0.158	.001	.008	3	5
LIVER	TP53I13 →	+2.964	+0.236	.008	.006	3	4
SOFT_TISSUE	CABYR →	+3.530	+0.213	<.001	.008	3	4
OESOPHAGUS	ZNF442 →	+0.635	+0.189	.001	.001	3	4
BREAST	CHP1 →	+0.661	+0.208	.009	.002	3	4
BREAST	ATP1B1 →	+1.938	+0.231	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099173 vs CAPN2 — BREAST

Explore this scatter interactively →