Presynapse organization

Across TCGA patient cohorts, RNA activity of the Presynapse organization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IL16, COL14A1, and SASH3, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynapse organization activity versus IL16 in HNSC (Pearson r = -0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IL16 →	-0.493	-0.035	<.001	<.001	3	8
LSCC	COL14A1 →	-0.667	-0.052	.001	.001	3	7
HNSC	SASH3 →	-0.342	-0.040	<.001	<.001	3	7
LSCC	STK10 →	-0.297	-0.048	<.001	<.001	3	7
HNSC	EVL →	-0.472	-0.038	<.001	.002	2	8
OV	HCLS1 →	-0.479	-0.026	.003	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099172 vs IL16 — HNSC

Explore this scatter interactively →