Presynaptic modulation of chemical synaptic transmission

Across TCGA patient cohorts, RNA activity of the Presynaptic modulation of chemical synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP2R5E, MARK4_S438, and NPEPPS, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynaptic modulation of chemical synaptic transmission activity versus PPP2R5E in COAD (Pearson r = 0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PPP2R5E →	+0.171	+0.026	<.001	<.001	3	5
LUAD	MARK4_S438 →	+0.224	+0.051	.001	.001	3	5
GBM	NPEPPS →	+0.291	+0.071	<.001	<.001	3	4
PDAC	DKK3 →	+0.534	+0.025	<.001	<.001	3	4
LUAD	UACA →	-0.360	-0.076	<.001	<.001	3	4
GBM	TBX2_S360 →	-0.641	-0.053	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099171 vs PPP2R5E — COAD

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