Presynaptic modulation of chemical synaptic transmission

Across TCGA patient cohorts, RNA activity of the Presynaptic modulation of chemical synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PHBP7, MIR4446, and ZNF491, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynaptic modulation of chemical synaptic transmission activity versus PHBP7 in GBM (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PHBP7 →	+0.584	+0.242	<.001	.006	3	5
HNSC	MIR4446 →	+0.806	+0.381	.007	.007	3	4
GBM	ZNF491 →	+0.592	+0.237	<.001	.002	3	4
BRCA	STAU2P1 →	+0.281	+0.469	<.001	<.001	3	3
BRCA	TOM1L1 →	-0.800	-0.537	<.001	<.001	3	3
BRCA	RASSF6 →	-1.094	-0.637	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099171 vs PHBP7 — GBM

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