Presynaptic modulation of chemical synaptic transmission

Across TCGA cell cohorts, RNA activity of the Presynaptic modulation of chemical synaptic transmission pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HIP1, GIPC1, and ADAM28, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HIP1 grouped by Presynaptic modulation of chemical synaptic transmission-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HIP1 →	-0.261	-0.701	<.001	<.001	3	7
BONE	GIPC1 →	-0.403	-1.549	.002	.008	3	5
BLOOD_Leukemia	ADAM28 →	+0.162	+1.041	.009	.005	3	5
BLOOD_Myeloma	MAPK9 →	-0.307	-1.752	.003	<.001	3	5
CNS	WDR18 →	-0.258	-1.053	.002	<.001	3	5
LUNG_NSCLC_LUSC	AP1G2 →	-0.250	-1.335	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HIP1 by Presynaptic modulation of chemical synaptic transmission activity — LUNG_NSCLC_LUAD

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