Presynaptic modulation of chemical synaptic transmission

Across TCGA cell cohorts, RNA activity of the Presynaptic modulation of chemical synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are APOBEC3D, FKBP14, and FKBP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, APOBEC3D grouped by Presynaptic modulation of chemical synaptic transmission-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	APOBEC3D →	+1.080	+1.198	.007	.009	2	4
KIDNEY	FKBP14 →	-1.235	-0.843	<.001	.009	3	3
STOMACH	FKBP3 →	-0.726	-0.718	.002	.004	3	3
STOMACH	PSMC6 →	-0.524	-0.734	.001	.003	3	3
STOMACH	RPL36AL →	-0.937	-0.939	.001	.005	3	3
STOMACH	NEMF →	-0.664	-0.729	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

APOBEC3D by Presynaptic modulation of chemical synaptic transmission activity — BONE

Explore this box plot interactively →