Presynaptic modulation of chemical synaptic transmission

Across TCGA cell cohorts, RNA activity of the Presynaptic modulation of chemical synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF493, ASTE1, and CUL4B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Presynaptic modulation of chemical synaptic transmission activity versus ZNF493 in URINARY_TRACT (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZNF493 →	+1.712	+1.954	<.001	.005	3	4
URINARY_TRACT	ASTE1 →	+0.585	+1.712	.001	.005	2	5
BLOOD_Myeloma	CUL4B →	+0.846	+1.227	.004	.002	3	4
BLOOD_Myeloma	BANF1 →	+1.092	+1.364	<.001	.007	3	4
LARGE_INTESTINE	IFT81 →	+0.583	+0.713	.008	.007	3	4
BLOOD_Leukemia	TOX →	+2.991	+0.691	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099171 vs ZNF493 — URINARY_TRACT

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