Postsynaptic modulation of chemical synaptic transmission

Across TCGA patient cohorts, RNA activity of the Postsynaptic modulation of chemical synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NUP153, FBXO2, and ATP6V0A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic modulation of chemical synaptic transmission activity versus NUP153 in GBM (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NUP153 →	-0.235	-0.088	<.001	<.001	3	5
GBM	FBXO2 →	+0.662	+0.084	<.001	<.001	3	5
OV	ATP6V0A1 →	+0.671	+0.041	<.001	.001	3	4
PDAC	SEC16A_S1305 →	+0.439	+0.046	<.001	<.001	3	4
GBM	CEP170B_S337 →	+0.752	+0.089	<.001	<.001	3	4
LSCC	ESYT1_S324 →	+0.376	+0.031	.003	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099170 vs NUP153 — GBM

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