Postsynaptic modulation of chemical synaptic transmission

Across TCGA patient cohorts, RNA activity of the Postsynaptic modulation of chemical synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PI16, FGFR3, and CHRDL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic modulation of chemical synaptic transmission activity versus PI16 in PDAC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PI16 →	+0.964	+0.822	.001	.001	3	4
OV	FGFR3 →	-1.218	-0.568	.007	.004	3	3
PDAC	CHRDL1 →	+0.775	+0.488	.001	.005	3	3
GBM	SCN1B →	+0.736	+0.188	<.001	<.001	3	3
PDAC	C7 →	+1.261	+0.639	.004	.005	3	3
GBM	HRC →	+0.299	+0.178	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099170 vs PI16 — PDAC

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