Postsynaptic modulation of chemical synaptic transmission

Across TCGA patient cohorts, RNA activity of the Postsynaptic modulation of chemical synaptic transmission pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CHGA_S142, NEFH_S540, and NEFH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic modulation of chemical synaptic transmission activity versus CHGA_S142 in OV (Pearson r = 0.02).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CHGA_S142 →	+2.559	+0.916	<.001	<.001	3	4
GBM	NEFH_S540 →	+1.534	+0.363	<.001	<.001	3	4
GBM	NEFH →	+1.498	+0.357	<.001	<.001	3	4
GBM	NEFL →	+1.216	+0.345	<.001	<.001	3	4
GBM	NEFM_S685 →	+1.426	+0.319	<.001	<.001	3	4
GBM	INA →	+1.209	+0.351	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099170 vs CHGA_S142 — OV

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