Postsynaptic modulation of chemical synaptic transmission

Across TCGA cell cohorts, RNA activity of the Postsynaptic modulation of chemical synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPK2, HIVEP3, and PICALM, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RIPK2 grouped by Postsynaptic modulation of chemical synaptic transmission-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RIPK2 →	+1.557	+0.317	.005	.001	3	5
LUNG_NSCLC_LUSC	HIVEP3 →	+1.346	+0.212	.006	.005	3	5
OESOPHAGUS	PICALM →	+1.099	+0.305	<.001	<.001	3	5
BREAST	EMP1 →	+1.811	+0.178	.006	.001	2	6
BREAST	CCDC82 →	+1.451	+0.187	.001	<.001	3	5
BLOOD_Lymphoma	KLHL23 →	+1.500	+0.272	.005	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RIPK2 by Postsynaptic modulation of chemical synaptic transmission activity — BLOOD_Leukemia

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