Postsynaptic modulation of chemical synaptic transmission

Across TCGA cell cohorts, RNA activity of the Postsynaptic modulation of chemical synaptic transmission pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELL3, AKNAD1, and MN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic modulation of chemical synaptic transmission activity versus ELL3 in SOFT_TISSUE (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ELL3 →	+2.170	+0.307	.004	.007	2	5
PANCREAS	AKNAD1 →	-0.500	-0.226	.009	.006	3	4
OESOPHAGUS	MN1 →	-1.462	-0.270	.001	.004	3	4
LUNG_NSCLC_LUAD	LSR →	+1.568	+0.173	.003	.007	3	4
LUNG_NSCLC_LUAD	ARHGAP8 →	+1.915	+0.248	<.001	.003	3	4
CNS	COL16A1 →	-1.945	-0.195	.005	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099170 vs ELL3 — SOFT_TISSUE

Explore this scatter interactively →