Regulation of modification of postsynaptic structure

Across TCGA cell cohorts, RNA activity of the Regulation of modification of postsynaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are USP5, OXCT2, and KLHDC4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, USP5 grouped by Regulation of modification of postsynaptic structure-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	USP5 →	+0.705	+1.031	<.001	.001	3	4
LARGE_INTESTINE	OXCT2 →	+0.567	+0.911	.007	.004	3	4
LARGE_INTESTINE	KLHDC4 →	+0.875	+0.924	.002	.009	2	5
LARGE_INTESTINE	KMT2A →	+0.700	+0.969	.003	.002	3	4
LARGE_INTESTINE	ZNF236 →	+0.617	+0.849	.006	.004	3	4
LARGE_INTESTINE	HEXIM2 →	+0.787	+0.942	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

USP5 by Regulation of modification of postsynaptic structure activity — BLOOD_Leukemia

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