Regulation of modification of postsynaptic structure

Across TCGA cell cohorts, RNA activity of the Regulation of modification of postsynaptic structure pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCDC107, SYCP2, and STX7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of modification of postsynaptic structure activity versus CCDC107 in BONE (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CCDC107 →	-1.057	-1.194	.008	.005	3	5
BONE	SYCP2 →	-1.713	-1.135	<.001	<.001	3	4
LUNG_NSCLC_LUAD	STX7 →	+0.622	+0.602	.003	.002	3	3
BLOOD_Myeloma	ARMCX6 →	-1.170	-0.145	.009	.001	2	4
OESOPHAGUS	TAF1A →	+0.974	+0.988	.006	.007	3	3
LIVER	SH3D19 →	-0.704	-1.104	.008	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099159 vs CCDC107 — BONE

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