Regulation of postsynaptic density assembly

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic density assembly pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM220A, AP4B1, and AK3P5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic density assembly activity versus FAM220A in BRCA (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	FAM220A →	+0.417	+0.491	.001	.009	3	4
OV	AP4B1 →	-0.633	-0.872	.002	.001	3	4
LSCC	AK3P5 →	-0.578	-0.168	<.001	.003	3	4
GBM	KLHL7 →	+0.357	+0.257	.009	.006	3	3
PDAC	P4HA1 →	+0.657	+0.164	.002	.009	3	3
PDAC	ANXA7 →	+0.139	+0.129	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099151 vs FAM220A — BRCA

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