Regulation of postsynaptic density assembly

Across TCGA cell cohorts, RNA activity of the Regulation of postsynaptic density assembly pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NHS, MAP2K5, and EVI2A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic density assembly activity versus NHS in STOMACH (Pearson r = 0.98).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	NHS →	+1.995	+0.768	<.001	.006	3	4
OESOPHAGUS	MAP2K5 →	-1.123	-0.280	<.001	.001	3	3
OVARY	EVI2A →	+0.106	+0.450	.009	<.001	3	3
OVARY	SLC44A5 →	+1.170	+0.449	<.001	.001	2	4
OVARY	AP1G2 →	+1.196	+0.443	<.001	.002	3	3
CNS	TNFAIP1 →	-0.629	-0.291	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099151 vs NHS — STOMACH

Explore this scatter interactively →