Regulation of postsynaptic specialization assembly

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic specialization assembly pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BICD2, NAV1, and NCS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic specialization assembly activity versus BICD2 in PDAC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	BICD2 →	+0.225	+0.061	<.001	<.001	3	5
LSCC	NAV1 →	+0.386	+0.045	<.001	<.001	3	5
GBM	NCS1 →	+0.542	+0.053	<.001	<.001	3	5
LUAD	UBE2E2 →	+0.384	+0.061	.001	<.001	3	4
LSCC	CAMSAP2 →	+0.399	+0.073	<.001	<.001	3	4
LUAD	CAMSAP2_S599 →	+0.475	+0.065	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099150 vs BICD2 — PDAC

Explore this scatter interactively →