Regulation of postsynaptic specialization assembly

Across TCGA cell cohorts, RNA activity of the Regulation of postsynaptic specialization assembly pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTK2B, C11orf80, and SPATA20, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic specialization assembly activity versus PTK2B in URINARY_TRACT (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PTK2B →	+1.861	+0.102	.004	.003	3	10
UPPER_AERODIGESTIVE_TRACT	C11orf80 →	+0.817	+0.100	<.001	<.001	3	8
BREAST	SPATA20 →	-1.494	-0.107	<.001	<.001	3	8
KIDNEY	ADRA2C →	-1.332	-0.114	.004	<.001	3	8
LIVER	HECA →	+1.096	+0.105	.001	.002	3	7
URINARY_TRACT	LRFN1 →	-1.471	-0.140	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099150 vs PTK2B — URINARY_TRACT

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