Regulation of postsynaptic specialization assembly

Across TCGA cell cohorts, RNA activity of the Regulation of postsynaptic specialization assembly pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GSR, APOLD1, and DNAL1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GSR grouped by Regulation of postsynaptic specialization assembly-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GSR →	-0.214	-0.746	<.001	.006	3	3
BLOOD_Leukemia	APOLD1 →	+0.248	+0.864	.004	.003	3	3
OESOPHAGUS	DNAL1 →	+0.121	+1.297	.009	.006	3	3
UPPER_AERODIGESTIVE_TRACT	RNF32 →	-0.218	-0.549	.002	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	CDH2 →	-0.141	-0.428	.003	.008	2	4
BREAST	ELF2 →	+0.162	+0.976	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GSR by Regulation of postsynaptic specialization assembly activity — BLOOD_Leukemia

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