Regulation of postsynaptic specialization assembly

Across TCGA cell cohorts, RNA activity of the Regulation of postsynaptic specialization assembly pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STK19, RRP9, and WDR54, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic specialization assembly activity versus STK19 in BLOOD_Leukemia (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	STK19 →	-0.498	-0.582	.001	.004	3	4
LUNG_NSCLC_LUAD	RRP9 →	-0.622	-0.770	.001	.006	3	4
LUNG_NSCLC_LUAD	WDR54 →	-1.049	-0.666	<.001	.009	3	4
BREAST	HCCS →	-0.948	-0.980	.003	.003	3	4
PANCREAS	C8orf76 →	-0.651	-1.097	.001	.007	3	3
PANCREAS	MTIF2 →	-0.483	-0.887	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099150 vs STK19 — BLOOD_Leukemia

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