Regulation of postsynaptic neurotransmitter receptor internalization

Across TCGA cell cohorts, RNA activity of the Regulation of postsynaptic neurotransmitter receptor internalization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POLR1E, UQCRB, and KIAA0895, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic neurotransmitter receptor internalization activity versus POLR1E in OVARY (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	POLR1E →	-1.207	-1.339	<.001	.002	3	6
LARGE_INTESTINE	UQCRB →	-0.848	-1.271	.005	<.001	3	5
BLOOD_Lymphoma	KIAA0895 →	+1.473	+0.791	<.001	.003	2	6
OVARY	LINC02693 →	-1.698	-1.329	<.001	.004	2	6
KIDNEY	HMGA1 →	-3.445	-1.628	.001	.006	3	4
PANCREAS	NOP14 →	-0.714	-0.878	.002	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099149 vs POLR1E — OVARY

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