Regulation of postsynaptic neurotransmitter receptor internalization

Across TCGA cell cohorts, RNA activity of the Regulation of postsynaptic neurotransmitter receptor internalization pathway is significantly associated with the protein abundance of multiple proteins, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RALA, EEF2, and SRM, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic neurotransmitter receptor internalization activity versus RALA in SOFT_TISSUE (Pearson r = 0.66).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RALA →	+1.271	+1.088	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	EEF2 →	-1.185	-1.127	.007	.002	3	11
UPPER_AERODIGESTIVE_TRACT	SRM →	-1.956	-1.613	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	EIF3A →	-1.117	-1.157	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	ETF1 →	-1.884	-1.346	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	ABCE1 →	-1.323	-1.456	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099149 vs RALA — SOFT_TISSUE

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