Microtubule-based protein transport

Across TCGA patient cohorts, RNA activity of the Microtubule-based protein transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TOPORS_T205, FOXO1, and HDAC7, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule-based protein transport activity versus TOPORS_T205 in BRCA (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TOPORS_T205 →	+0.474	+0.045	.005	.007	3	5
PDAC	FOXO1 →	-0.233	-0.025	.001	.003	3	5
GBM	HDAC7 →	-0.211	-0.067	.001	.007	3	5
GBM	IRF2BPL →	-0.302	-0.075	<.001	.001	3	5
GBM	CAMSAP3 →	+0.603	+0.088	<.001	<.001	3	5
HNSC	EPB41L1 →	+0.580	+0.060	.002	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099118 vs TOPORS_T205 — BRCA

Explore this scatter interactively →