Microtubule-based protein transport

Across TCGA patient cohorts, RNA activity of the Microtubule-based protein transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGF12-AS2, EPHX1, and MAP1A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule-based protein transport activity versus FGF12-AS2 in LSCC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FGF12-AS2 →	+1.225	+0.829	<.001	<.001	3	4
HNSC	EPHX1 →	+0.855	+0.863	.004	<.001	3	4
LSCC	MAP1A →	+1.084	+0.990	<.001	<.001	3	4
LSCC	SRRM3 →	+1.037	+0.882	<.001	<.001	3	4
GBM	TNK2 →	+0.585	+0.333	<.001	<.001	3	4
LSCC	MAPRE3 →	+0.542	+0.592	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099118 vs FGF12-AS2 — LSCC

Explore this scatter interactively →