Microtubule-based protein transport

Across TCGA cell cohorts, RNA activity of the Microtubule-based protein transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATAD2B, PRCC, and B3GNTL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GATAD2B grouped by Microtubule-based protein transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GATAD2B →	+0.951	+1.781	.001	<.001	3	6
BREAST	PRCC →	+0.625	+0.992	.003	<.001	3	4
LUNG_NSCLC_LUAD	B3GNTL1 →	-1.137	-0.904	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CDC42EP2 →	-1.324	-1.171	.002	.002	3	4
OESOPHAGUS	FUBP1 →	+0.445	+0.612	.001	.001	3	4
OESOPHAGUS	ZFP3 →	+1.165	+0.571	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GATAD2B by Microtubule-based protein transport activity — BONE

Explore this box plot interactively →