tRNA 5'-end processing

Across TCGA cell cohorts, RNA activity of the tRNA 5'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADD1, AP1S2, and G6PC3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADD1 grouped by tRNA 5'-end processing-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	ADD1 →	-0.663	-0.173	<.001	.001	3	5
BLOOD_Lymphoma	AP1S2 →	-1.559	-0.454	.002	.001	3	4
LARGE_INTESTINE	G6PC3 →	-0.798	-0.214	.003	<.001	2	5
LARGE_INTESTINE	PTPN23 →	-0.544	-0.141	<.001	.001	3	4
LUNG_NSCLC_LUSC	RPP38 →	-0.691	-0.201	<.001	.007	3	4
SOFT_TISSUE	PNPLA6 →	-1.201	-0.276	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADD1 by tRNA 5'-end processing activity — OESOPHAGUS

Explore this box plot interactively →