tRNA 5'-end processing

Across TCGA cell cohorts, RNA activity of the tRNA 5'-end processing pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL26A1, DOCK5, and DDB2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA 5'-end processing activity versus COL26A1 in SKIN (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	COL26A1 →	+0.292	+0.146	.004	.008	3	6
BLOOD_Lymphoma	DOCK5 →	-1.920	-0.119	.007	.003	3	5
BLOOD_Leukemia	DDB2 →	-1.467	-0.177	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PARP1 →	+1.620	+0.300	.002	.002	3	5
LIVER	PLEK2 →	-3.662	-0.219	.001	.009	3	5
BREAST	SERPINB8 →	-1.000	-0.141	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099116 vs COL26A1 — SKIN

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