Microtubule-based transport

Across TCGA cell cohorts, RNA activity of the Microtubule-based transport pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF11, GOT2, and MARS2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Microtubule-based transport activity versus RNF11 in BONE (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RNF11 →	+1.131	+0.266	.004	.004	3	6
UPPER_AERODIGESTIVE_TRACT	GOT2 →	-1.062	-0.227	<.001	.008	3	6
PANCREAS	MARS2 →	-0.803	-0.176	.002	.003	3	6
LARGE_INTESTINE	TIMP2 →	+2.822	+0.204	.003	.001	3	6
UPPER_AERODIGESTIVE_TRACT	RPL4 →	-0.898	-0.234	<.001	.006	3	6
BONE	UBTD1 →	+1.778	+0.172	.004	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099111 vs RNF11 — BONE

Explore this scatter interactively →