Postsynaptic specialization organization

Across TCGA patient cohorts, RNA activity of the Postsynaptic specialization organization pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CEP170, DBN1, and SYTL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic specialization organization activity versus CEP170 in LSCC (Pearson r = -0.01).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CEP170 →	+0.216	+0.036	<.001	<.001	3	7
LSCC	DBN1 →	+0.367	+0.041	<.001	<.001	3	5
COAD	SYTL1 →	-0.747	-0.036	<.001	.001	3	5
PDAC	VCL_Y822 →	+0.285	+0.036	.009	.004	3	5
PDAC	CSNK1A1 →	-0.156	-0.029	.006	<.001	3	5
LUAD	CLEC3B →	+0.242	+0.028	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099084 vs CEP170 — LSCC

Explore this scatter interactively →