Postsynaptic specialization organization

Across TCGA patient cohorts, RNA activity of the Postsynaptic specialization organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPN5, TEK, and DIPK2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic specialization organization activity versus PTPN5 in GBM (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PTPN5 →	+1.814	+0.841	<.001	<.001	3	5
CCRCC	TEK →	+1.568	+0.922	<.001	<.001	3	5
CCRCC	DIPK2B →	+1.122	+0.736	<.001	.002	3	5
CCRCC	ROBO4 →	+1.088	+0.728	<.001	.005	3	5
BRCA	PCDH7 →	+0.721	+0.563	.003	.003	3	5
CCRCC	S1PR1 →	+1.099	+0.653	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099084 vs PTPN5 — GBM

Explore this scatter interactively →