Postsynaptic specialization organization

Across TCGA cell cohorts, RNA activity of the Postsynaptic specialization organization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZMAT2, NBPF14, and GTF2H2C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZMAT2 grouped by Postsynaptic specialization organization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ZMAT2 →	+0.708	+1.217	.009	.002	3	5
LUNG_SCLC	NBPF14 →	+2.035	+1.347	.006	.001	3	5
OVARY	GTF2H2C →	-0.745	-0.740	.002	.005	3	5
SOFT_TISSUE	XYLB →	-1.152	-1.443	<.001	.001	3	4
SOFT_TISSUE	SLC31A2 →	+1.682	+1.292	.001	.002	3	4
SOFT_TISSUE	OLFML2A →	+2.341	+1.122	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZMAT2 by Postsynaptic specialization organization activity — SOFT_TISSUE

Explore this box plot interactively →