Postsynaptic specialization organization

Across TCGA cell cohorts, RNA activity of the Postsynaptic specialization organization pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EEF1A1, ATP1A3, and ST13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Postsynaptic specialization organization activity versus EEF1A1 in STOMACH (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	EEF1A1 →	+0.945	+1.489	<.001	.002	3	4
BLOOD_Lymphoma	ATP1A3 →	+2.191	+1.093	.004	.001	3	4
URINARY_TRACT	ST13 →	+0.632	+1.230	<.001	.001	3	4
URINARY_TRACT	CLPP →	+0.787	+1.129	.003	.004	3	4
URINARY_TRACT	HDGFL2 →	+0.709	+1.275	.004	<.001	3	4
PANCREAS	HJURP →	+0.873	+1.277	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099084 vs EEF1A1 — STOMACH

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