Regulation of postsynaptic membrane neurotransmitter receptor levels

Across TCGA patient cohorts, RNA activity of the Regulation of postsynaptic membrane neurotransmitter receptor levels pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1443, PRKAB2, and WDR47_S312, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of postsynaptic membrane neurotransmitter receptor levels activity versus MAP1B_S1443 in LUAD (Pearson r = 0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MAP1B_S1443 →	+1.172	+0.033	.004	.005	3	5
UCEC	PRKAB2 →	+0.248	+0.030	.002	.003	3	5
LSCC	WDR47_S312 →	+0.434	+0.026	.002	.002	3	4
LUAD	ADSS1 →	+0.562	+0.023	<.001	<.001	3	4
LUAD	GMFB →	+0.126	+0.021	.005	.002	3	4
COAD	GNPTG →	+0.186	+0.018	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099072 vs MAP1B_S1443 — LUAD

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