Regulation of postsynaptic membrane neurotransmitter receptor levels

Across TCGA cell cohorts, RNA activity of the Regulation of postsynaptic membrane neurotransmitter receptor levels pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SF3A2, C1RL, and PLEKHM2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SF3A2 grouped by Regulation of postsynaptic membrane neurotransmitter receptor levels-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SF3A2 →	-0.503	-0.254	.009	.004	3	4
BREAST	C1RL →	-1.317	-0.155	.002	.008	3	4
LIVER	PLEKHM2 →	-0.827	-0.377	.005	.005	2	4
PANCREAS	EGLN3 →	+1.298	+0.262	.004	.002	3	3
PANCREAS	INPP5E →	-0.882	-0.418	<.001	<.001	3	3
PANCREAS	ZNF608 →	+1.967	+0.255	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SF3A2 by Regulation of postsynaptic membrane neurotransmitter receptor levels activity — PANCREAS

Explore this box plot interactively →