Clearance of foreign intracellular nucleic acids

Across TCGA patient cohorts, RNA activity of the Clearance of foreign intracellular nucleic acids pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNF213, APOBEC3C, and SKAP2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clearance of foreign intracellular nucleic acids activity versus RNF213 in HNSC (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF213 →	+0.424	+0.074	<.001	<.001	3	8
BRCA	APOBEC3C →	+0.685	+0.084	<.001	<.001	3	8
LSCC	SKAP2 →	+0.468	+0.079	<.001	<.001	3	8
BRCA	CYBA →	+0.514	+0.047	<.001	<.001	3	8
BRCA	CYBB →	+0.628	+0.058	<.001	<.001	3	8
GBM	FMNL1 →	+0.472	+0.351	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099046 vs RNF213 — HNSC

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