Clearance of foreign intracellular nucleic acids

Across TCGA patient cohorts, RNA activity of the Clearance of foreign intracellular nucleic acids pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD72, VAV1, and ITGB2-AS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Clearance of foreign intracellular nucleic acids activity versus CD72 in BRCA (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CD72 →	+0.787	+0.800	<.001	<.001	3	4
BRCA	VAV1 →	+0.532	+0.593	.005	.002	3	4
BRCA	ITGB2-AS1 →	+1.132	+0.775	<.001	<.001	3	4
UCEC	MCM5 →	+0.751	+0.224	.005	.002	2	4
UCEC	PSME2 →	+0.927	+0.130	.002	.006	3	3
UCEC	CENPA →	+1.064	+0.216	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099046 vs CD72 — BRCA

Explore this scatter interactively →