Clearance of foreign intracellular nucleic acids

Across TCGA cell cohorts, RNA activity of the Clearance of foreign intracellular nucleic acids pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPDC1, TRIM3, and ATN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NPDC1 grouped by Clearance of foreign intracellular nucleic acids-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NPDC1 →	-3.321	-1.608	<.001	<.001	3	4
BREAST	TRIM3 →	-1.944	-1.069	.003	.002	3	4
SOFT_TISSUE	ATN1 →	-1.071	-1.583	.003	<.001	3	4
OVARY	CTH →	+1.568	+1.062	.005	.002	3	4
BREAST	HOXA3 →	+1.167	+0.879	.009	.005	3	4
BREAST	DSE →	+1.198	+0.963	.006	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NPDC1 by Clearance of foreign intracellular nucleic acids activity — SOFT_TISSUE

Explore this box plot interactively →