Vesicle tethering to Golgi

Across TCGA patient cohorts, RNA activity of the Vesicle tethering to Golgi pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SRP72_T571, ANP32A, and COLGALT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering to Golgi activity versus SRP72_T571 in UCEC (Pearson r = -0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SRP72_T571 →	-0.497	-0.064	<.001	<.001	3	5
LUAD	ANP32A →	+0.347	+0.037	<.001	<.001	3	5
OV	COLGALT1 →	-0.354	-0.054	<.001	<.001	3	5
BRCA	CKAP4_S26 →	-0.923	-0.050	<.001	<.001	3	5
BRCA	KCTD14 →	-0.774	-0.036	.003	.004	3	5
CCRCC	P4HB →	-0.340	-0.027	.002	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099041 vs SRP72_T571 — UCEC

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