Vesicle tethering to Golgi

Across TCGA patient cohorts, RNA activity of the Vesicle tethering to Golgi pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRK2, INTS10, and RNU6-933P, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering to Golgi activity versus LRRK2 in HNSC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LRRK2 →	-0.846	-0.604	<.001	.005	3	3
GBM	INTS10 →	-0.205	-0.805	.001	<.001	3	3
GBM	RNU6-933P →	-0.217	-0.742	.003	.003	3	3
HNSC	FNBP1 →	-0.411	-0.494	.004	.004	3	3
BRCA	FAM238A →	-0.233	-0.745	.001	<.001	3	3
BRCA	SNX18P5 →	-0.079	-0.578	.006	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099041 vs LRRK2 — HNSC

Explore this scatter interactively →