Vesicle tethering to Golgi

Across TCGA patient cohorts, RNA activity of the Vesicle tethering to Golgi pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RING1_S232, ARFGAP3_S143, and TBC1D23_S520, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering to Golgi activity versus RING1_S232 in GBM (Pearson r = -0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RING1_S232 →	-1.020	-1.394	<.001	<.001	3	3
BRCA	ARFGAP3_S143 →	+1.126	+1.720	<.001	<.001	2	4
GBM	TBC1D23_S520 →	+0.511	+1.128	<.001	<.001	3	3
OV	C17orf75 →	+0.462	+0.477	<.001	<.001	3	3
LSCC	RICTOR_S1588 →	+0.603	+1.692	<.001	<.001	3	2
LUAD	SLC16A2_S532 →	-0.517	-0.813	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099041 vs RING1_S232 — GBM

Explore this scatter interactively →