Vesicle tethering to Golgi

Across TCGA cell cohorts, RNA activity of the Vesicle tethering to Golgi pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNF227, PGD, and COX6A1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNF227 grouped by Vesicle tethering to Golgi-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RNF227 →	+0.854	+1.697	.001	<.001	3	5
LUNG_NSCLC_LUSC	PGD →	+2.058	+1.202	.009	.004	3	5
LUNG_SCLC	COX6A1 →	+0.663	+1.372	.009	.001	3	5
LUNG_NSCLC_LUAD	C11orf49 →	+0.713	+0.893	.001	.001	3	5
PANCREAS	ZNF280C →	+0.603	+1.366	.004	<.001	3	5
BONE	LMBRD1 →	+0.806	+1.447	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNF227 by Vesicle tethering to Golgi activity — KIDNEY

Explore this box plot interactively →