Vesicle tethering to Golgi

Across TCGA cell cohorts, RNA activity of the Vesicle tethering to Golgi pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM189B, EAF1, and GBP3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering to Golgi activity versus FAM189B in BREAST (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FAM189B →	-0.990	-0.525	.001	<.001	3	6
PANCREAS	EAF1 →	-0.572	-0.255	.003	.003	3	5
BONE	GBP3 →	+4.580	+0.595	<.001	.001	3	5
CNS	GPR68 →	+1.931	+0.360	<.001	.002	2	5
OESOPHAGUS	TGFBI →	+4.418	+0.302	<.001	.004	3	4
BLOOD_Myeloma	TIMM17B →	-0.535	-0.451	.009	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099041 vs FAM189B — BREAST

Explore this scatter interactively →