Vesicle tethering

Across TCGA patient cohorts, RNA activity of the Vesicle tethering pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL3, RPL7, and TCEAL4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering activity versus RPL3 in BRCA (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RPL3 →	-0.403	-0.038	<.001	<.001	3	6
GBM	RPL7 →	-0.392	-0.043	<.001	<.001	3	6
BRCA	TCEAL4 →	+0.419	+0.024	.002	.005	3	6
GBM	COLGALT1 →	-0.490	-0.049	<.001	<.001	3	6
BRCA	AGFG2 →	+0.332	+0.038	.001	<.001	3	6
GBM	EEF2 →	-0.272	-0.062	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099022 vs RPL3 — BRCA

Explore this scatter interactively →