Vesicle tethering

Across TCGA patient cohorts, RNA activity of the Vesicle tethering pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NUP88, MTBP, and RNGTT, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering activity versus NUP88 in UCEC (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NUP88 →	-0.517	-0.228	<.001	<.001	3	5
LSCC	MTBP →	-0.594	-0.158	<.001	<.001	3	5
GBM	RNGTT →	-0.312	-0.099	<.001	<.001	3	5
GBM	NDUFAF4 →	-0.527	-0.096	<.001	.005	3	5
GBM	AGTPBP1 →	-0.539	-0.123	<.001	<.001	3	5
GBM	NARS2 →	-0.234	-0.084	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099022 vs NUP88 — UCEC

Explore this scatter interactively →