Vesicle tethering

Across TCGA cell cohorts, RNA activity of the Vesicle tethering pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UGGT1, WDR33, and TXNIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UGGT1 grouped by Vesicle tethering-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	UGGT1 →	-0.638	-1.213	.002	<.001	3	4
CNS	WDR33 →	-0.469	-0.910	<.001	<.001	3	4
BREAST	TXNIP →	+1.410	+0.677	.004	.003	3	4
SKIN	RFX7 →	-0.556	-1.073	<.001	.001	3	4
LIVER	ANLN →	+1.160	+1.265	.001	<.001	3	3
LIVER	ACTR3 →	+0.935	+1.349	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UGGT1 by Vesicle tethering activity — URINARY_TRACT

Explore this box plot interactively →