Vesicle tethering

Across TCGA cell cohorts, RNA activity of the Vesicle tethering pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALG6, ZNF300, and IL6R, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle tethering activity versus ALG6 in CNS (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ALG6 →	+0.832	+0.307	<.001	.002	3	3
BLOOD_Myeloma	ZNF300 →	-2.873	-0.529	<.001	.001	3	3
BLOOD_Myeloma	IL6R →	-2.827	-0.462	.007	.006	3	3
BLOOD_Myeloma	FAM111A →	+0.978	+0.366	.001	.006	3	3
URINARY_TRACT	CHRAC1 →	-0.952	-0.608	.008	.002	3	3
URINARY_TRACT	HTATIP2 →	+0.982	+0.383	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0099022 vs ALG6 — CNS

Explore this scatter interactively →